Felix Ratjen Selected Research

Tobramycin (Nebcin)

1/2019	Eradication of early P. aeruginosa infection in children <7 years of age with cystic fibrosis: The early study.
1/2019	Oral Azithromycin and Response to Pulmonary Exacerbations Treated with Intravenous Tobramycin in Children with Cystic Fibrosis.
11/2018	Early detection using qPCR of Pseudomonas aeruginosa infection in children with cystic fibrosis undergoing eradication treatment.
7/2017	Pilot trial of tobramycin inhalation powder in cystic fibrosis patients with chronic Burkholderia cepacia complex infection.
5/2017	Effectiveness of a stepwise Pseudomonas aeruginosa eradication protocol in children with cystic fibrosis.
3/2014	Effectiveness of inhaled tobramycin in eradicating Pseudomonas aeruginosa in children with cystic fibrosis.
4/2010	Treatment of early Pseudomonas aeruginosa infection in patients with cystic fibrosis: the ELITE trial.
12/2009	Aminoglycoside therapy against Pseudomonas aeruginosa in cystic fibrosis: a review.
8/2008	Rapid pulmonary delivery of inhaled tobramycin for Pseudomonas infection in cystic fibrosis: a pilot project.
7/2008	A pilot study to compare tobramycin 80 mg injectable preparation with 300 mg solution for inhalation in cystic fibrosis patients.

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Felix Ratjen Research Topics

Disease

135	Cystic Fibrosis (Mucoviscidosis) 12/2022 - 02/2002
39	Infections 12/2021 - 06/2005
38	Lung Diseases (Lung Disease) 04/2022 - 07/2002
18	Inflammation (Inflammations) 01/2022 - 03/2004
12	Pseudomonas Infections 10/2020 - 03/2007
8	Persistent Infection 01/2020 - 07/2008
5	Airway Obstruction (Choking) 01/2014 - 11/2004
4	Cough 01/2022 - 05/2010
3	Fever (Fevers) 01/2020 - 06/2002
3	Disease Progression 10/2017 - 05/2011
3	Pneumonia (Pneumonitis) 08/2014 - 09/2004
3	Respiratory Tract Diseases (Respiratory Tract Disease) 07/2013 - 01/2009
2	Ciliary Motility Disorders (Primary Ciliary Dyskinesia) 01/2022 - 09/2011
2	Allergic Bronchopulmonary Aspergillosis 01/2020 - 11/2019
2	Empyema 01/2020 - 01/2017
2	Bronchitis 11/2019 - 09/2009
2	Weight Gain 07/2012 - 06/2007
2	Asthma (Bronchial Asthma) 09/2010 - 04/2004
2	Body Weight (Weight, Body) 05/2010 - 06/2007
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2022
1	Headache (Headaches) 11/2021
1	Pancreatitis 01/2021
1	Gastritis 01/2021
1	Acidosis 01/2021
1	Burkholderia Infections 12/2020
1	Malnutrition (Nutritional Deficiencies) 01/2020
1	Pleural Empyema (Pyothorax) 01/2020
1	Liver Diseases (Liver Disease) 11/2019
1	Pancreatic Diseases (Pancreatic Disease) 10/2019
1	Polymicrogyria 01/2019
1	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 01/2019
1	Intestinal Obstruction (Obstruction, Intestinal) 01/2019
1	Rupture 01/2019
1	Exanthema (Rash) 01/2017
1	Fibrosis (Cirrhosis) 01/2017

Drug/Important Bio-Agent (IBA)

36	Anti-Bacterial Agents (Antibiotics)IBA 01/2022 - 06/2002
16	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2022 - 07/2002
15	Pharmaceutical PreparationsIBA 01/2022 - 05/2007
14	ivacaftorIBA 01/2022 - 11/2011
12	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 01/2020 - 10/2008
11	Tobramycin (Nebcin)FDA LinkGeneric 01/2019 - 06/2007
8	ChloridesIBA 12/2022 - 05/2007
8	lumacaftorIBA 01/2022 - 01/2015
8	dornase alfa (Pulmozyme)FDA Link 01/2020 - 03/2004
6	Azithromycin (Zithromax)FDA LinkGeneric 10/2019 - 05/2010
6	SolutionsIBA 01/2019 - 07/2008
6	ArginaseIBA 08/2014 - 12/2005
6	Arginine (L-Arginine)FDA Link 01/2014 - 06/2006
5	Biomarkers (Surrogate Marker)IBA 11/2021 - 01/2019
4	ivacaftor drug combination tezacaftorIBA 12/2022 - 01/2021
4	elexacaftorIBA 12/2022 - 01/2021
4	Chloride Channels (Chloride Channel)IBA 01/2021 - 05/2007
4	Bronchodilator Agents (Bronchodilators)IBA 01/2021 - 01/2014
4	Proteins (Proteins, Gene)FDA Link 01/2021 - 06/2002
3	InterleukinsIBA 01/2022 - 06/2005
3	Nitric Oxide Synthase (NO Synthase)IBA 01/2022 - 05/2011
3	NitrogenIBA 01/2020 - 02/2002
3	EnzymesIBA 01/2020 - 05/2011
3	Surface-Active Agents (Surfactants)IBA 11/2019 - 11/2004
3	DNA (Deoxyribonucleic Acid)IBA 11/2018 - 03/2007
3	Tiotropium Bromide (Spiriva)FDA Link 09/2015 - 01/2014
2	Oxygen (Dioxygen)IBA 01/2022 - 01/2018
2	Transaminases (Aminotransferases)IBA 01/2021 - 01/2017
2	Deoxyribonucleases (DNase)FDA Link 01/2020 - 03/2004
2	Tissue Plasminogen Activator (Alteplase)FDA Link 01/2020 - 01/2017
2	Expectorants (Mucolytics)IBA 01/2020 - 03/2007
2	LipidsIBA 11/2019 - 09/2004
2	beta-Aminoethyl Isothiourea (AET)IBA 11/2018 - 05/2017
2	Ion Channels (Ion Channel)IBA 01/2015 - 01/2012
2	AgarIBA 01/2014 - 01/2014
2	Sulfhydryl Compounds (Thiols)IBA 07/2013 - 01/2009
2	AerosolsIBA 10/2012 - 04/2004
2	CytokinesIBA 05/2010 - 12/2008
2	Interleukin-10 (Interleukin 10)IBA 12/2008 - 06/2005
1	Nitrogen OxidesIBA 01/2022
1	Interleukin-1beta (Interleukin 1 beta)IBA 01/2022
1	riociguatIBA 11/2021
1	Phospholipids (Phosphatides)FDA LinkGeneric 11/2019
1	TrypsinogenIBA 10/2019
1	Clostridium perfringens epsilon-toxinIBA 01/2019
1	EndoglinIBA 01/2019
1	Indicators and Reagents (Reagents)IBA 01/2019
1	Biological ProductsIBA 10/2017
1	PowdersIBA 07/2017
1	Pentetic Acid (DTPA)FDA LinkGeneric 01/2017

Therapy/Procedure

55	Therapeutics 04/2022 - 02/2002
4	Drug Therapy (Chemotherapy) 01/2021 - 11/2007
3	Lung Transplantation 09/2013 - 04/2009
2	Precision Medicine 11/2021 - 10/2016
2	Transplantation 12/2020 - 09/2017
2	Chest Tubes (Chest Tube) 01/2020 - 01/2017
2	Patient Readmission 01/2020 - 01/2017
2	Length of Stay 01/2020 - 01/2017
2	Gastrostomy 11/2019 - 01/2019
2	Terminal Care (Care, Terminal) 01/2018 - 05/2014
2	Injections 01/2014 - 07/2008
2	Nebulizers and Vaporizers (Inhaler) 01/2014 - 04/2004
2	Pleurodesis 12/2012 - 04/2009
1	High-Protein Diet 01/2020
1	Flowmeters 01/2020